Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles
- Regev-Rudzki, N; Wilson, DW; Carvalho, TG; Sisquella, X; Coleman, BM; Rug, M; Bursac, D; Angrisano, F; Gee, M; Hill, AF; Baum, J; Cowman, AF;
Publication Year 2013-05-23, Volume 153, Issue #5, Page 1120-1133
- Journal Title
- Publication Type
- Journal Article
- Cell-cell communication is an important mechanism for information exchange promoting cell survival for the control of features such as population density and differentiation. We determined that Plasmodium falciparum-infected red blood cells directly communicate between parasites within a population using exosome-like vesicles that are capable of delivering genes. Importantly, communication via exosome-like vesicles promotes differentiation to sexual forms at a rate that suggests that signaling is involved. Furthermore, we have identified a P. falciparum protein, PfPTP2, that plays a key role in efficient communication. This study reveals a previously unidentified pathway of P. falciparum biology critical for survival in the host and transmission to mosquitoes. This identifies a pathway for the development of agents to block parasite transmission from the human host to the mosquito.
- CELL PRESS
- PLASMODIUM-FALCIPARUM; HOST-CELL; MICROPARTICLES; MEMBRANE; PROTEINS; ERYTHROCYTES; NANOTUBES; MECHANISM; BINDING; DIFFERENTIATION
- WEHI Research Division(s)
- Infection And Immunity
- Publisher's Version
- Rights Notice
- Copyright © 2013 Elsevier Inc. All rights reserved.
Creation Date: 2013-05-23 12:00:00Last Modified: 0001-01-01 12:00:00