Structural Basis of the Interaction of the Breast Cancer Oncogene LMO4 with the Tumour Suppressor CtIP/RBBP8
- Author(s)
- Stokes, PH; Liew, CW; Kwan, AH; Foo, P; Barker, HE; Djamirze, A; O'Reilly, V; Visvader, JE; Mackay, JP; Matthews, JM;
- Details
- Publication Year 2013-04-12,Volume 425,Issue #7,Page 1101-1110
- Journal Title
- JOURNAL OF MOLECULAR BIOLOGY
- Publication Type
- Journal Article
- Abstract
- LIM-only protein 4 (LMO4) is strongly linked to the progression of breast cancer. Although the mechanisms underlying this phenomenon are not well understood, a role is emerging for LMO4 in regulation of the cell cycle. We determined the solution structure of LMO4 in complex with CtIP (C-terminal binding protein interacting protein)/RBBP8, a tumour suppressor protein that is involved in cell cycle progression, DNA repair and transcriptional regulation. Our data reveal that CtIP and the essential LMO cofactor LDB1 (LIM-domain binding protein 1) bind to the same face on LMO4 and cannot simultaneously bind to LMO4. We hypothesise that overexpression of LMO4 may disrupt some of the normal tumour suppressor activities of CUP, thereby contributing to breast cancer progression. (C) 2013 Elsevier Ltd. All rights reserved.
- Publisher
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
- Keywords
- LIM domains; protein–protein interactions; breast cancer; cell cycle control; intrinsically disordered domains
- Research Division(s)
- Stem Cells And Cancer
- Publisher's Version
- https://doi.org/10.1016/j.jmb.2013.01.017
- Terms of Use/Rights Notice
- Copyright © 2013 Elsevier Ltd. All rights reserved.
Creation Date: 2013-04-12 12:00:00