Targeting of a natural killer cell receptor family by a viral immunoevasin
Details
Publication Year 2013-07, Volume 14, Issue #7, Page 699-705
Journal Title
NATURE IMMUNOLOGY
Publication Type
Journal Article
Abstract
Activating and inhibitory receptors on natural killer (NK) cells have a crucial role in innate immunity, although the basis of the engagement of activating NK cell receptors is unclear. The activating receptor Ly49H confers resistance to infection with murine cytomegalovirus by binding to the 'immunoevasin' m157. We found that m157 bound to the helical stalk of Ly49H, whereby two m157 monomers engaged the Ly49H dimer. The helical stalks of Ly49H lay centrally across the m157 platform, whereas its lectin domain was not required for recognition. Instead, m157 targeted an 'aromatic peg motif' present in stalks of both activating and inhibitory receptors of the Ly49 family, and substitution of this motif abrogated binding. Furthermore, ligation of m157 to Ly49H or Ly49C resulted in intracellular signaling. Accordingly, m157 has evolved to 'tackle the legs' of a family of NK cell receptors.
Publisher
NATURE PUBLISHING GROUP
Keywords
CLASS-I LIGAND; MURINE CYTOMEGALOVIRUS M157; MOUSE CYTOMEGALOVIRUS; ACTIVATION RECEPTOR; CRYSTAL-STRUCTURE; CRITICAL RESIDUES; BINDING-SITE; RECOGNITION; COMPLEX; INFECTION
WEHI Research Division(s)
Structural Biology
Publisher's Version
https://doi.org/10.1038/ni.2605
Rights Notice
© 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.


Creation Date: 2013-07-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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