CD8(+) T cell help is required for efficient induction of EAE in Lewis rats
- Author(s)
- Camara, M; Beyersdorf, N; Fischer, HJ; Herold, MJ; Ip, CW; van den Brandt, J; Toyka, KV; Taurog, JD; Hunig, T; Herrmann, T; Reichardt, HM; Weishaupt, A; Kerkau, T;
- Details
- Publication Year 2013-07-15,Volume 260,Issue #1-2,Page 17-27
- Journal Title
- JOURNAL OF NEUROIMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The role of CD8(+) T cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease activity of EAE both in Lewis rats, depleted of CD8(+) T cells by monoclonal antibodies and CD8 knockout rats, which was accompanied by reduced leukocyte infiltration into the spinal cord. We detected myelin basic protein (MBP)-specific CD4(+) T cells in peripheral lymphoid organs of CD8-depleted animals which, however, failed to differentiate into interferon-gamma-producing effector cells. Our results indicate that CD8(+) T cells interact with myelin-specific CD4(+) T cells early in EAE enabling them to differentiate into pathogenic effector cells. (C) 2013 Elsevier B.V. All rights reserved.
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MYELIN BASIC-PROTEIN; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; CORTICAL DEMYELINATION; MONOCLONAL-ANTIBODIES; IMMUNE TOLERANCE; ANTIGEN THERAPY; INFLAMMATION
- Research Division(s)
- Molecular Genetics Of Cancer
- Publisher's Version
- https://doi.org/10.1016/j.jneuroim.2013.04.014
- Terms of Use/Rights Notice
- Copyright © 2013 Elsevier B.V. All rights reserved.
Creation Date: 2013-07-15 12:00:00