Genetic Loci for Retinal Arteriolar Microcirculation

Sim, X; Jensen, RA; Ikram, MK; Cotch, MF; Li, XH; MacGregor, S; Xie, J; Smith, AV; Boerwinkle, E; Mitchell, P; Klein, R; Klein, BEK; Glazer, NL; Lumley, T; McKnight, B; Psaty, BM; de Jong, PTVM; Hofman, A; Rivadeneira, F; Uitterlinden, AG; van Duijn, CM; Aspelund, T; Eiriksdottir, G; Harris, TB; Jonasson, F; Launer, LJ; Attia, J; Baird, PN; Harrap, S; Holliday, EG; Inouye, M; Rochtchina, E; Scott, RJ; Viswanathan, A; Li, G; Smith, NL; Wiggins, KL; Kuo, JZ; Taylor, KD; Hewitt, AW; Martin, NG; Montgomery, GW; Sun, C; Young, TL; Mackey, DA; van Zuydam, NR; Doney, ASF; Palmer, CNA; Morris, AD; Rotter, JI; Tai, ES; Gudnason, V; Vingerling, JR; Siscovick, DS; Wang, JJ; Wong, TY

Author(s): Sim, X; Jensen, RA; Ikram, MK; Cotch, MF; Li, XH; MacGregor, S; Xie, J; Smith, AV; Boerwinkle, E; Mitchell, P; Klein, R; Klein, BEK; Glazer, NL; Lumley, T; McKnight, B; Psaty, BM; de Jong, PTVM; Hofman, A; Rivadeneira, F; Uitterlinden, AG; van Duijn, CM; Aspelund, T; Eiriksdottir, G; Harris, TB; Jonasson, F; Launer, LJ; Attia, J; Baird, PN; Harrap, S; Holliday, EG; Inouye, M; Rochtchina, E; Scott, RJ; Viswanathan, A; Li, G; Smith, NL; Wiggins, KL; Kuo, JZ; Taylor, KD; Hewitt, AW; Martin, NG; Montgomery, GW; Sun, C; Young, TL; Mackey, DA; van Zuydam, NR; Doney, ASF; Palmer, CNA; Morris, AD; Rotter, JI; Tai, ES; Gudnason, V; Vingerling, JR; Siscovick, DS; Wang, JJ; Wong, TY;
Details: Publication Year 2013-06-12,Volume 8,Issue #6,Page e51692
Journal Title: PLOS ONE
Publication Type: Journal Article
Abstract: Narrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a genome-wide association study in 18,722 unrelated individuals of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium and the Blue Mountain Eye Study, to identify genetic determinants associated with variations in retinal arteriolar caliber. Retinal vascular calibers were measured on digitized retinal photographs using a standardized protocol. One variant (rs2194025 on chromosome 5q14 near the myocyte enhancer factor 2C MEF2C gene) was associated with retinal arteriolar caliber in the meta-analysis of the discovery cohorts at genome-wide significance of P-value <5x10(-8). This variant was replicated in an additional 3,939 individuals of European ancestry from the Australian Twins Study and Multi-Ethnic Study of Atherosclerosis (rs2194025, P-value = 2.11x10(-12) in combined meta-analysis of discovery and replication cohorts). In independent studies of modest sample sizes, no significant association was found between this variant and clinical outcomes including coronary artery disease, stroke, myocardial infarction or hypertension. In conclusion, we found one novel loci which underlie genetic variation in microvasculature which may be relevant to vascular disease. The relevance of these findings to clinical outcomes remains to be determined.
Publisher: PUBLIC LIBRARY SCIENCE
Keywords: Coronary artery disease ; genetic loci ; hypertenstion ; ischemic stroke ; meta analysis
Research Division(s): Infection And Immunity
Link To PubMed Central Version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680438/
Publisher's Version: https://doi.org/10.1371/journal.pone.0065804
Open Access at Publisher's Site: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0065804
Terms of Use/Rights Notice: Copyright: © 2012 Hill et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Documents: journal.pone.0065804.pdf - (1.33MB, application/pdf)

Creation Date: 2013-06-12 12:00:00