Ecdysone Receptors: From the Ashburner Model to Structural Biology
- Author(s)
- Hill, RJ; Billas, IML; Bonneton, F; Graham, LD; Lawrence, MC;
- Journal Title
- ANNUAL REVIEW OF ENTOMOLOGY
- Publication Type
- Journal Article
- Abstract
- In 1974, Ashburner and colleagues postulated a model to explain the control of the puffing sequence on Drosophila polytene chromosomes initiated by the molting hormone 20-hydroxyecdysone. This model inspired a generation of molecular biologists to clone and characterize elements of the model, thereby providing insights into the control of gene networks by steroids, diatomic gases, and other small molecules. It led to the first cloning of the EcR subunit of the heterodimeric EcR-USP ecdysone receptor. X-ray diffraction studies of the ligand-binding domain of the receptor are elucidating the specificity of receptor-ecdysteroid interactions, the selectivity of some environmentally friendly insecticides, the evolution of the EcR-USP heterodimer, and indeed Ashburner's classical biochemical evidence for the central role of the ecdysone receptor in his model.
- Publisher
- ANNUAL REVIEWS
- Keywords
- SEQUENTIAL GENE ACTIVATION; LIGAND-BINDING DOMAIN; SALIVARY-GLAND CHROMOSOMES; VON DROSOPHILA MELANOGASTER; RETINOID-X-RECEPTORS; ANTERIOR SILK GLAND; REV-ERB-BETA; NUCLEAR RECEPTORS; POLYTENE CHROMOSOMES; ECDYSTEROID RECEPTOR
- Research Division(s)
- Structural Biology
- Publisher's Version
- https://doi.org/10.1146/annurev-ento-120811-153610
- Terms of Use/Rights Notice
- ANNUAL REVIEWS, INC.
Creation Date: 2013-01-01 12:00:00