Inhibitor of Apoptosis (IAP) Proteins-Modulators of Cell Death and Inflammation
- Details
- Publication Year 2013-02,Volume 5,Issue #2,Page pii: a008730
- Journal Title
- COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
- Publication Type
- Journal Article
- Abstract
- Misregulated innate immune signaling and cell death form the basis of much human disease pathogenesis. Inhibitor of apoptosis (IAP) protein family members are frequently overexpressed in cancer and contribute to tumor cell survival, chemo-resistance, disease progression, and poor prognosis. Although best known for their ability to regulate caspases, IAPs also influence ubiquitin (Ub)-dependent pathways that modulate innate immune signaling via activation of nuclear factor kappa B (NF-kappa B). Recent research into IAP biology has unearthed unexpected roles for this group of proteins. In addition, the advances in our understanding of the molecular mechanisms that IAPs use to regulate cell death and innate immune responses have provided new insights into disease states and suggested novel intervention strategies. Here we review the functions assigned to those IAP proteins that act at the intersection of cell death regulation and inflammatory signaling.
- Publisher
- COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
- Keywords
- NF-KAPPA-B; NECROSIS-FACTOR RECEPTOR; INNATE IMMUNE-RESPONSE; NEGATIVE BACTERIAL-INFECTION; ALPHA-DEPENDENT APOPTOSIS; CHAIN ASSEMBLY COMPLEX; TOLL-LIKE-RECEPTORS; VIVO RNAI ANALYSIS; UBIQUITIN LIGASE; DROSOPHILA INHIBITOR
- Research Division(s)
- Cell Signalling And Cell Death
- Publisher's Version
- https://doi.org/10.1101/cshperspect.a008730
- Terms of Use/Rights Notice
- Copyright © 2013 by Cold Spring Harbor Laboratory Press
Creation Date: 2013-02-01 12:00:00