Synthesis of Biotinylated Episilvestrol: Highly Selective Targeting of the Translation Factors eIF4AI/II
Details
Publication Year 2013-03-15, Volume 15, Issue #6, Page 1406-1409
Journal Title
ORGANIC LETTERS
Publication Type
Journal Article
Abstract
Silvestrol (1) and episilvestrol (2) are protein synthesis inhibitors, and the former has shown efficacy in multiple mouse models of cancer; however, the selectivity of these potent cytotoxic natural products has not been described. Herein, it is demonstrated that eukaryotic initiation factors eIF4AI/II were the only proteins detected to bind silvestrol (1) and biotinylated episilvestrol (9) by affinity purification. Our study demonstrates the remarkable selectivity of these promising chemotherapeutics.
Publisher
AMER CHEMICAL SOC
Keywords
MESSENGER-RNAS; PROTEIN DHX29; SILVESTROL; INHIBITORS; (-)-SILVESTROL; INITIATION; (-)-EPISILVESTROL; DERIVATIVES; MECHANISM; ANALOGS
WEHI Research Division(s)
Chemical Biology
Publisher's Version
https://doi.org/10.1021/ol400401d
Rights Notice
Copyright © 2013 American Chemical Society


Creation Date: 2013-03-15 12:00:00
Last Modified: 0001-01-01 12:00:00
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