Mcl-1 is essential for the survival of plasma cells
- Author(s)
- Peperzak, V; Vikstrom, I; Walker, J; Glaser, SP; LePage, M; Coquery, CM; Erickson, LD; Fairfax, K; Mackay, F; Strasser, A; Nutt, SL; Tarlinton, DM;
- Details
- Publication Year 2013-03,Volume 14,Issue #3,Page 290-297
- Journal Title
- NATURE IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The long-term survival of plasma cells is entirely dependent on signals derived from their environment. These extrinsic factors presumably induce and sustain the expression of antiapoptotic proteins of the Bcl-2 family. It is uncertain whether there is specificity among Bcl-2 family members in the survival of plasma cells and whether their expression is linked to specific extrinsic factors. We found here that deletion of the gene encoding the antiapoptotic protein Mcl-1 in plasma cells resulted in rapid depletion of this population in vivo. Furthermore, we found that the receptor BCMA was needed to establish high expression of Mcl-1 in bone marrow but not spleen plasma cells and that establishing this survival pathway preceded the component of plasma cell differentiation that depends on the transcriptional repressor Blimp-1. Our results identify a critical role for Mcl-1 in the maintenance of plasma cells.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- MEMORY B-CELLS; BONE-MARROW; MULTIPLE-MYELOMA; SMALLPOX VACCINATION; RHEUMATOID-ARTHRITIS; INADEQUATE RESPONSE; CUTTING EDGE; PHASE-II; EXPRESSION; APRIL
- Research Division(s)
- Cancer And Haematology; Molecular Genetics Of Cancer; Immunology; Molecular Immunology
- Link To PubMed Central Version
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041127/
- Publisher's Version
- https://doi.org/10.1038/ni.2527
- Terms of Use/Rights Notice
- © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Creation Date: 2013-03-01 12:00:00