Enhanced survival of lung tissue-resident memory CD8(+) T cells during infection with influenza virus due to selective expression of IFITM3
- Author(s)
- Wakim, LM; Gupta, N; Mintern, JD; Villadangos, JA;
- Details
- Publication Year 2013-03,Volume 14,Issue #3,Page 238-245
- Journal Title
- NATURE IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Infection with influenza virus results in the deposition of anti-influenza CD8(+) resident memory T cells (T-RM cells) in the lung. As a consequence of their location in the lung mucosal tissue, these cells are exposed to cytopathic pathogens over the life of the organism and may themselves be susceptible to infection. Here we found that lung T-RM cells selectively maintained expression of the interferon-induced transmembrane protein IFITM3, a protein that confers broad resistance to viral infection. Lung T-RM cells that lacked IFITM3 expression were more susceptible to infection than were their normal counterparts and were selectively lost during a secondary bout of infection. Thus, lung T-RM cells were programmed to retain IFITM3 expression, which facilitated their survival and protection from viral infection during subsequent exposures.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- WEST NILE VIRUS; DENGUE VIRUS; PROTEINS; ANTIGEN; BRAIN
- Research Division(s)
- Inflammation
- Publisher's Version
- https://doi.org/10.1038/ni.2525
- Terms of Use/Rights Notice
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Creation Date: 2013-03-01 12:00:00