Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
- Author(s)
- Strasser, A; Cory, S; Adams, JM;
- Details
- Publication Year 2011-09-14,Volume 30,Issue #18,Page 3667-3683
- Journal Title
- EMBO JOURNAL
- Publication Type
- Journal Article
- Abstract
- Apoptosis, the major form of programmed cell death in metazoan organisms, plays critical roles in normal development, tissue homeostasis and immunity, and its disturbed regulation contributes to many pathological states, including cancer, autoimmunity, infection and degenerative disorders. In vertebrates, it can be triggered either by engagement of 'death receptors' of the tumour necrosis factor receptor family on the cell surface or by diverse intracellular signals that act upon the Bcl-2 protein family, which controls the integrity of the mitochondrial outer membrane through the complex interactions of family members. Both pathways lead to cellular demolition by dedicated proteases termed caspases. This review discusses the groundbreaking experiments from many laboratories that have clarified cell death regulation and galvanised efforts to translate this knowledge into novel therapeutic strategies for the treatment of malignant and perhaps certain autoimmune and infectious diseases. The EMBO Journal (2011) 30, 3667-3683. doi: 10.1038/emboj.2011.307; Published online 23 August 2011
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- apoptosis ; Bcl-2 protein family ; cancer therapy ; mitochondria ; tumourigenesis
- Research Division(s)
- Molecular Genetics Of Cancer
- Publisher's Version
- https://doi.org/10.1038/emboj.2011.307
- Open Access at Publisher's Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173800/- Terms of Use/Rights Notice
- Copyright © 2011, European Molecular Biology Organization
Creation Date: 2011-09-14 12:00:00