Mediator Subunit 12 Is Required for Neutrophil Development in Zebrafish
Details
Publication Year 2011-08-25, Volume 6, Issue #8, Page -
Journal Title
PLOS ONE
Publication Type
Journal Article
Abstract
Hematopoiesis requires the spatiotemporal organization of regulatory factors to successfully orchestrate diverse lineage specificity from stem and progenitor cells. Med12 is a regulatory component of the large Mediator complex that enables contact between the general RNA polymerase II transcriptional machinery and enhancer bound regulatory factors. We have identified a new zebrafish med12 allele, syr, with a single missense mutation causing a valine to aspartic acid change at position 1046. Syr shows defects in hematopoiesis, which predominantly affect the myeloid lineage. Syr has identified a hematopoietic cell-specific requirement for Med12, suggesting a new role for this transcriptional regulator.
Publisher
PUBLIC LIBRARY SCIENCE
Keywords
TRANSGENIC ZEBRAFISH; MENTAL-RETARDATION; GENE-EXPRESSION; NEURAL CREST; COMPLEX; TRANSCRIPTION; COACTIVATOR; MYC; ASSOCIATION; ERYTHROPOIESIS
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Creation Date: 2011-08-25 12:00:00
Last Modified: 0001-01-01 12:00:00
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