Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors
Details
Publication Year 2011-10-01, Volume 21, Issue #19, Page 5992-5994
Journal Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Publication Type
Journal Article
Abstract
4-Aminobenzothieno[3,2-d]pyrimidines were previously identified in a high throughput screening campaign as LIMK1 inhibitors. Scaffold reversal led to the identification of a series of simple 5,6-substituted 4-aminothieno[2,3-d] pyrimidines with low micromolar inhibition of LIMK1. (C) 2011 Elsevier Ltd. All rights reserved.
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
KINASES
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2011-10-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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