Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors
- Author(s)
- Sleebs, BE; Nikolakopoulos, G; Street, IP; Falk, H; Baell, JB;
- Details
- Publication Year 2011-10-01,Volume 21,Issue #19,Page 5992-5994
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Publication Type
- Journal Article
- Abstract
- 4-Aminobenzothieno[3,2-d]pyrimidines were previously identified in a high throughput screening campaign as LIMK1 inhibitors. Scaffold reversal led to the identification of a series of simple 5,6-substituted 4-aminothieno[2,3-d] pyrimidines with low micromolar inhibition of LIMK1. (C) 2011 Elsevier Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- KINASES
- Publisher's Version
- https://doi.org/10.1016/j.bmcl.2011.07.050
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2011-10-01 12:00:00