Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance
Details
Publication Year 2011-09-01, Volume 118, Issue #9, Page 2462-2472
Journal Title
BLOOD
Publication Type
Journal Article
Abstract
To investigate the role of Aire in thymic selection, we examined the cellular requirements for generation of ovalbumin (OVA)-specific CD4 and CD8 T cells in mice expressing OVA under the control of the rat insulin promoter. Aire deficiency reduced the number of mature single-positive OVA-specific CD4(+) or CD8(+) T cells in the thymus, independent of OVA expression. Importantly, it also contributed in 2 ways to OVA-dependent negative selection depending on the T-cell type. Aire-dependent negative selection of OVA-specific CD8 T cells correlated with Aire-regulated expression of OVA. By contrast, for OVA-specific CD4 T cells, Aire affected tolerance induction by a mechanism that operated independent of the level of OVA expression, controlling access of antigen presenting cells to medullary thymic epithelial cell (mTEC)-expressed OVA. This study supports the
Publisher
AMER SOC HEMATOLOGY
Keywords
T-CELLS; EPITHELIAL-CELLS; SELF-TOLERANCE; ILLUMINA MICROARRAY; AUTOIMMUNE-DISEASE; INSULIN EXPRESSION; DEFICIENT MICE; IDDM2 LOCUS; GENE; SELECTION
Rights Notice
Copyright © 2013 by American Society of Hematology


Creation Date: 2011-09-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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