The regulation of TNF signalling: what a tangled web we weave
- Author(s)
- Silke, J;
- Details
- Publication Year 2011-10,Volume 23,Issue #5,Page 620-626
- Journal Title
- CURRENT OPINION IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- In the past 2 years there has been an explosion of information regarding molecules that regulate TNF-R1 signalling, and even reviews published in 2010 are out of date. TNF-R1 activation of NE-kappa B is a text book example of a signal transduction pathway regulated by ubiquitin and many of the concepts concerning the different roles of ubiquitin chains were first outlined in TNF-R1 signalling. What was once a very simple pathway with clearly defined roles for ubiquitin in regulating TNF-R1 signalling has, however, now become so complicated that we have an embarrassment of riches' [1]. The less polite might claim our pathways of TNF-R1 signalling look as complicated as a web constructed by a drug-addled spider [2]. This review will pick apart only one small strand of the web, and will address the role of ubiquitin in the activation of NF-kappa B by TNF with a focus on interpreting in vivo results. Nevertheless some of the concepts, for example the role of linear ubiquitin chains in regulating signalling, may be applicable to the family in general.
- Publisher
- CURRENT BIOLOGY LTD
- Keywords
- NF-KAPPA-B; NECROSIS-FACTOR RECEPTOR; LINEAR POLYUBIQUITIN CHAINS; TOLL-LIKE-RECEPTORS; CELL-DEATH; INFLAMMATORY RESPONSES; ASSEMBLY COMPLEX; ACTIVATION; APOPTOSIS; ALPHA
- Research Division(s)
- Cell Signalling And Cell Death
- Publisher's Version
- https://doi.org/10.1016/j.coi.2011.08.002
- Terms of Use/Rights Notice
- Copyright © 2011 Elsevier Ltd. All rights reserved.
Creation Date: 2011-10-01 12:00:00