Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors
Publication Year 2011-10, Volume 2, Issue #10, Page 982-986
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- Journal Article
- 7-Phenyl-4-aminobenzothieno[3,2-d]pyrimidines were previously reported to exhibit moderate LIMK1 inhibition. Further exploration of SAR around the 7-phenyl moiety has led to the development of a lead series with an increased potency for LIMK1. Evaluation of physicochemical and ADME properties, and off-target kinase screens has seen this novel series emerge as a promising platform for a set of tool compounds for evaluating LIMK as a therapeutic target.
- ROYAL SOC CHEMISTRY
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Creation Date: 2011-10-01 12:00:00Last Modified: 0001-01-01 12:00:00