Thrombopoietin and hematopoietic stem cells
- Author(s)
- de Graaf, CA; Metcalf, D;
- Details
- Publication Year 2011-05-15,Volume 10,Issue #10,Page 1582-1589
- Journal Title
- CELL CYCLE
- Publication Type
- Journal Article
- Abstract
- Thrombopoietin (TPO) is the cytokine that is chiefly responsible for megakaryocyte production but increasingly attention has turned to its role in maintaining hematopoietic stem cells (HSCs). HSCs are required to initiate the production of all mature hematopoietic cells, but this differentiation needs to be balanced against self-renewal and quiescence to maintain the stem cell pool throughout life. TPO has been shown to support HSC quiescence during adult hematopoiesis, with the loss of TPO signaling associated with bone marrow failure and thrombocytopenia. Recent studies have shown that constitutive activation mutations in Mpl contribute to myeloproliferative disease. In this review, we will discuss TPO signaling pathways, regulation of TPO levels and the role of TPO in normal hematopoiesis and during myeloproliferative disease.
- Publisher
- LANDES BIOSCIENCE
- Keywords
- HUMAN MEGAKARYOCYTE GROWTH; COLONY-STIMULATING FACTOR; C-MPL LIGAND; CONGENITAL AMEGAKARYOCYTIC THROMBOCYTOPENIA; ERYTHROPOIETIN MESSENGER-RNA; TYROSINE PHOSPHORYLATION; IN-VIVO; PLATELET PRODUCTION; POLYCYTHEMIA-VERA; DEFICIENT MICE
- Research Division(s)
- Cancer And Haematology
- Link To PubMed Central Version
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127159/
- Publisher's Version
- https://doi.org/10.4161/cc.10.10.15619
- Open Access at Publisher's Site
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- Copyright © 2011 Landes Bioscience
Creation Date: 2011-05-15 12:00:00
Last Modified: 2014-12-23 12:06:03