B cell memory and the role of apoptosis in its formation
- Author(s)
- Vikstrom, I; Tarlinton, DM;
- Details
- Publication Year 2011-06,Volume 48,Issue #11,Page 1301-1306
- Journal Title
- MOLECULAR IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- B cell memory consists of quiescent memory B cell and bone marrow plasma cell populations, generated in germinal centers during immune responses to T cell dependent antigens. The regulation of cell survival, both within germinal centers and in the maintenance of the effector cells generated in this response, is central to the qualitative and quantitative regulation of memory. In spite of this, the pro- and anti-apoptotic molecules that control survival in these peri-antigenic B cell immune compartments are poorly defined. In this review, we discuss the current perception of the main apoptotic regulators of germinal center B cell, plasma cell, and memory B cell survival during the formation, affinity maturation and maintenance of immunological memory. (C) 2010 Elsevier Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- ANTIBODY-FORMING-CELLS; PROSURVIVAL BCL-2 PROTEINS; FOLLICULAR DENDRITIC CELLS; PRIMARY IMMUNE-RESPONSE; BH3 MIMETIC ABT-737; GERMINAL-CENTER; SOMATIC HYPERMUTATION; AFFINITY MATURATION; CLONAL SELECTION; IN-VIVO
- Publisher's Version
- https://doi.org/10.1016/j.molimm.2010.10.026
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2011-06-01 12:00:00