Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype
Details
Publication Year 2011-07-15, Volume 187, Issue #2, Page 842-850
Journal Title
JOURNAL OF IMMUNOLOGY
Publication Type
Journal Article
Abstract
Three surface molecules of mouse CD8(+) dendritic cells (DCs), also found on the equivalent human DC subpopulation, were compared as targets for Ab-mediated delivery of Ags, a developing strategy for vaccination. For the production of cytotoxic T cells, DEC-205 and Clec9A, but not Clec12A, were effective targets, although only in the presence of adjuvants. For Ab production, however, Clec9A excelled as a target, even in the absence of adjuvant. Potent humoral immunity was a result of the highly specific expression of Clec9A on DCs, which allowed longer residence of targeting Abs in the bloodstream, prolonged DC Ag presentation, and extended CD4 T cell proliferation, all of which drove highly efficient development of follicular helper T cells. Because Clec9A shows a similar expression pattern on human DCs, it has particular promise as a target for vaccines of human application. The Journal of Immunology, 2011, 187: 842-850.
Publisher
AMER ASSOC IMMUNOLOGISTS
Keywords
C-TYPE LECTIN; IMMUNE-RESPONSES; IN-VIVO; ANTIBODY-RESPONSES; CROSS-PRESENTATION; SUBSET; ACTIVATION; EXPRESSION; EFFICIENT; DEC-205
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Creation Date: 2011-07-15 12:00:00
Last Modified: 0001-01-01 12:00:00
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