SUMOylation of Blimp-1 promotes its proteasomal degradation
- Author(s)
- Shimshon, L; Michaeli, A; Hadar, R; Nutt, SL; David, Y; Navon, A; Waisman, A; Tirosh, B;
- Details
- Publication Year 2011-08,Volume 585,Issue #15,Page 2405-2409
- Journal Title
- FEBS LETTERS
- Publication Type
- Journal Article
- Abstract
- B lymphocyte induced maturation protein-1 (Blimp-1) is a transcription repressor of the Krueppel-like family. Blimp-1 plays important roles in developmental processes, such as of germ cells and hair follicle stem cells. In B lymphocytes Blimp-1 orchestrates the terminal differentiation into plasma cells. We discovered that Blimp-1 undergoes SUMOylation by SUMO-1. This SUMOylation is modulated by the SUMO protease SENP1. While Blimp-1 is relatively stable in 293T cells, a fusion with SUMO1 rendered it to rapid proteasomal degradation. Increase in SENP1 activity stabilized Blimp-1, while a decrease promoted its degradation. Our data indicate that SUMOylation of Blimp-1 regulates its intracellular stability. Structured summary of protein interactions: Blimp1 physically interacts with SUMO1 by anti tag coimmunoprecipitation (View Interaction 1, 2). SUMO1 physically interacts with Blimp1 by anti tag coimmunoprecipitation (View interaction). (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- SECRETING PLASMA-CELLS; TRANSCRIPTIONAL REPRESSION; B-CELLS; DIFFERENTIATION; LYMPHOMA; PRDI-BF1; LINEAGE; SWITCH; MICE
- Publisher's Version
- https://doi.org/10.1016/j.febslet.2011.06.022
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2011-08-01 12:00:00