Reference Intervals for Common Laboratory Tests in Melanesian Children
- Author(s)
- Manning, L; Laman, M; Townsend, MA; Chubb, SP; Siba, PM; Mueller, I; Davis, TME;
- Details
- Publication Year 2011-07,Volume 85,Issue #1,Page 50-54
- Journal Title
- AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- Publication Type
- Journal Article
- Abstract
- Pediatric reference intervals for biochemical tests are often derived from studies in Western countries and may not be applicable to the developing world. No such intervals exist for Melanesian populations. The aim of this study was to provide specific reference intervals for children from Papua New Guinea (PNG). We assayed plasma from 327 healthy Melanesian children living in Madang Province for common biochemical and hematological analytes. We used well-validated commercially available assay methodology. Compared with reference intervals from children from Western countries and/or African children, there were substantial differences in hemoglobin, soluble transferrin receptor, ferritin, calcium, phosphate, and C-reactive protein. Differences in the upper limits of reference intervals for bilirubin and alanine aminotransferase were also observed. Available reference intervals from Western and African countries may be inappropriate in PNG and other Melanesian countries. This has implications for clinical care and safety monitoring in pharmaceutical intervention trials and vaccine studies.
- Publisher
- AMER SOC TROP MED & HYGIENE
- Keywords
- C-REACTIVE PROTEIN; REFERENCE VALUES; MALARIA; POPULATION; INFECTIONS; DEFICIENCY; AGREEMENT; COUNTRY
- Publisher's Version
- https://doi.org/10.4269/ajtmh.2011.11-0095
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2011-07-01 12:00:00