The golden anniversary of the thymus
- Author(s)
- Miller, JFAP;
- Details
- Publication Year 2011-07,Volume 11,Issue #7,Page 489-495
- Journal Title
- NATURE REVIEWS IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The immunological function of the thymus was first documented 50 years ago by using neonatally thymectomized mice, while studying its role in virus-induced leukaemia. Since then, an enormous wealth of reports has helped to define the importance of this primary lymphoid organ. In this article, I summarize the key advances that have led to our current knowledge of the functions of the thymus and its T cells in immunity.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- T-CELL-RECEPTOR; NEONATALLY THYMECTOMIZED MICE; THORACIC DUCT LYMPHOCYTES; INDUCE POSITIVE SELECTION; HEMOLYSIN-FORMING CELLS; NEGATIVE SELECTION; ADULT-MOUSE; IMMUNOLOGICAL RESPONSIVENESS; ANTIBODY-PRODUCTION; IMMUNE RESPONSE
- Publisher's Version
- https://doi.org/10.1038/nri2993
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2011-07-01 12:00:00