The SOCS boxuAdapting proteins for ubiquitination and proteasomal degradation
- Author(s)
- Linossi, EM; Nicholson, SE;
- Details
- Publication Year 2012-04,Volume 64,Issue #4,Page 316-323
- Journal Title
- IUBMB LIFE
- Publication Type
- Journal Article
- Abstract
- The suppressor of cytokine signalling (SOCS) box was first identified in the SH2-containing SOCS box family (cytokine-inducible SH2-containing protein, SOCS17) and is a 40-amino acid motif, which functions to recruit an E3 ubiquitin ligase complex consisting of the adapter proteins elongins B and C, Rbx2 and the scaffold protein Cullin5. The SOCS box is found in a diverse array of intracellular signalling molecules, many of which contain different protein interaction domains such as SPRY and WD40 domains, leucine and ankyrin repeats or other functional domains such as GTPases. In general, the SOCS box-containing proteins are thought to act as substrate-recognition modules to mediate the polyubiquitination and subsequent degradation of substrate proteins by the 26S proteasome. (C) 2012 IUBMB Life, 64(4): 316323, 2012
- Publisher
- WILEY-BLACKWELL
- Keywords
- STIMULATING FACTOR-RECEPTOR; TUMOR-SUPPRESSOR PROTEIN; CYTOKINE SIGNALING SOCS; MICE LACKING SUPPRESSOR; ANKYRIN REPEAT; IN-VIVO; LIGASE COMPLEX; MEDIATED DEGRADATION; TARGETS FILAMINS; CREATINE-KINASE
- Research Division(s)
- Inflammation
- Publisher's Version
- https://doi.org/10.1002/iub.1011
- NHMRC Grants
- NHMRC/461219,
- Terms of Use/Rights Notice
- Copyright © 2012 Wiley Periodicals, Inc.
Creation Date: 2012-04-01 12:00:00
Last Modified: 2014-12-12 09:31:39