Biology and significance of the JAK/STAT signalling pathways
- Author(s)
- Kiu, H; Nicholson, SE;
- Details
- Publication Year 2012-04,Volume 30,Issue #2,Page 88-106
- Journal Title
- GROWTH FACTORS
- Publication Type
- Journal Article
- Abstract
- Since its discovery two decades ago, the activation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway by numerous cytokines and growth factors has resulted in it becoming one of the most well-studied intracellular signalling networks. The field has progressed from the identification of the individual components to high-resolution crystal structures of both JAK and STAT, and an understanding of the complexities of the molecular activation and deactivation cycle which results in a diverse, yet highly specific and regulated pattern of transcriptional responses. While there is still more to learn, we now appreciate how disruption and deregulation of this pathway can result in clinical disease and look forward to adoption of the next generation of JAK inhibitors in routine clinical treatment.
- Publisher
- INFORMA HEALTHCARE
- Keywords
- COLONY-STIMULATING FACTOR; PROTEIN-TYROSINE KINASE; STAT TRANSCRIPTION FACTORS; MICE LACKING SUPPRESSOR; PHOSPHORYLATION-ACETYLATION SWITCH; PHYSIOLOGICAL NEGATIVE REGULATOR; CYTOKINE RECEPTOR INTERACTION; UBIQUITIN-PROTEASOME PATHWAY; GTPASE-ACTIVATING PROTEIN; INTERFERON-ALPHA RECEPTOR
- Publisher's Version
- https://doi.org/10.3109/08977194.2012.660936
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2012-04-01 12:00:00