Subtype and pathway specific responses to anticancer compounds in breast cancer

Heiser, LM; Sadanandam, A; Kuo, WL; Benz, SC; Goldstein, TC; Ng, S; Gibb, WJ; Wang, NJ; Ziyad, S; Tong, F; Bayani, N; Hu, Z; Billig, JI; Dueregger, A; Lewis, S; Jakkula, L; Korkola, JE; Durinck, S; Pepin, F; Guan, YH; Purdom, E; Neuvial, P; Bengtsson, H; Wood, KW; Smith, PG; Vassilev, LT; Hennessy, BT; Greshock, J; Bachman, KE; Hardwicke, MA; Park, JW; Marton, LJ; Wolf, DM; Collisson, EA; Neve, RM; Mills, GB; Speed, TP; Feiler, HS; Wooster, RF; Haussler, D; Stuart, JM; Gray, JW; Spellman, PT

Author(s): Heiser, LM; Sadanandam, A; Kuo, WL; Benz, SC; Goldstein, TC; Ng, S; Gibb, WJ; Wang, NJ; Ziyad, S; Tong, F; Bayani, N; Hu, Z; Billig, JI; Dueregger, A; Lewis, S; Jakkula, L; Korkola, JE; Durinck, S; Pepin, F; Guan, YH; Purdom, E; Neuvial, P; Bengtsson, H; Wood, KW; Smith, PG; Vassilev, LT; Hennessy, BT; Greshock, J; Bachman, KE; Hardwicke, MA; Park, JW; Marton, LJ; Wolf, DM; Collisson, EA; Neve, RM; Mills, GB; Speed, TP; Feiler, HS; Wooster, RF; Haussler, D; Stuart, JM; Gray, JW; Spellman, PT;
Details: Publication Year 2012-02-21,Volume 109,Issue #8,Page 2724-2729
Journal Title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publication Type: Journal Article
Abstract: Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtypes and pathways found in tumors, suggesting that treatment of cell lines with candidate therapeutic compounds can guide identification of associations between molecular subtypes, pathways, and drug response. In a test of 77 therapeutic compounds, nearly all drugs showed differential responses across these cell lines, and approximately one third showed subtype-, pathway-, and/or genomic aberration-specific responses. These observations suggest mechanisms of response and resistance and may inform efforts to develop molecular assays that predict clinical response.
Publisher: NATL ACAD SCIENCES
Keywords: TAXOL-INDUCED APOPTOSIS; RAW COPY NUMBERS; CELL-LINES; KINASE INHIBITOR; FOXA1 EXPRESSION; BETA-CATENIN; RESISTANCE; CISPLATIN; ERBB2; CHEMOSENSITIVITY
Research Division(s): Bioinformatics
Link To PubMed Central Version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286973/
Publisher's Version: https://doi.org/10.1073/pnas.1018854108

Creation Date: 2012-02-21 12:00:00