Maintenance of T Cell Function in the Face of Chronic Antigen Stimulation and Repeated Reactivation for a Latent Virus Infection
- Author(s)
- Mackay, LK; Wakim, L; van Vliet, CJ; Jones, CM; Mueller, SN; Bannard, O; Fearon, DT; Heath, WR; Carbone, FR;
- Details
- Publication Year 2012-03-01,Volume 188,Issue #5,Page 2173-2178
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Persisting infections are often associated with chronic T cell activation. For certain pathogens, this can lead to T cell exhaustion and survival of what is otherwise a cleared infection. In contrast, for herpesviruses, T cells never eliminate infection once it is established. Instead, effective immunity appears to maintain these pathogens in a state of latency. We used infection with HSV to examine whether effector-type T cells undergoing chronic stimulation retained functional and proliferative capacity during latency and subsequent reactivation. We found that latency-associated T cells exhibited a polyfunctional phenotype and could secrete a range of effector cytokines. These T cells were also capable of mounting a recall proliferative response on HSV reactivation and could do so repeatedly. Thus, for this latent infection, T cells subjected to chronic Ag stimulation and periodic reactivation retain the ability to respond to local virus challenge. The Journal of Immunology, 2012, 188: 2173-2178.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- HERPES-SIMPLEX-VIRUS; CHRONIC VIRAL-INFECTION; HEPATITIS-C VIRUS; TRANSPLANT RECIPIENTS; REPLICATIVE FUNCTION; TRIGEMINAL GANGLIA; IMMUNE EVASION; EXHAUSTION; MEMORY; PERSISTENCE
- Research Division(s)
- Immunology
- Link To PubMed Central Version
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378511/
- Publisher's Version
- https://doi.org/10.4049/jimmunol.1102719
- Terms of Use/Rights Notice
- Copyright © 2012 by The American Association of Immunologists, Inc.
Creation Date: 2012-03-01 12:00:00