A histopathologic study of fatal paediatric cerebral malaria caused by mixed Plasmodium falciparum/Plasmodium vivax infections
- Author(s)
- Manning, L; Rosanas-Urgell, A; Laman, M; Edoni, H; McLean, C; Mueller, I; Siba, P; Davis, TME;
- Journal Title
- MALARIA JOURNAL
- Publication Type
- Journal Article
- Abstract
- Microvascular sequestration of Plasmodium falciparum underlies cerebral malaria. Despite suggestive ex vivo evidence, this phenomenon has not been convincingly demonstrated in coma complicating Plasmodium vivax malaria. Severely-ill Papua New Guinean children with mixed P. falciparum/P. vivax infections are more likely to develop cerebral malaria and die than those with P. falciparum alone, possibly reflecting P. vivax sequestration. Nested PCR was performed on post mortem brain tissue from three such children dying from cerebral malaria due to mixed-species infections. No P. vivax DNA was detected. These findings do not support the hypothesis that P. vivax sequestration occurs in human brain.
- Publisher
- BIOMED CENTRAL LTD
- Keywords
- FALCIPARUM-MALARIA; CLINICAL-FEATURES; FIELD SAMPLES; SEQUESTRATION; PAPUA; BRAIN
- Research Division(s)
- Infection And Immunity
- Publisher's Version
- https://doi.org/10.1186/1475-2875-11-107
- Open Access at Publisher's Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366883/- Terms of Use/Rights Notice
- © 2012 Manning et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creation Date: 2012-04-03 12:00:00