Nonplasmacytoid, High IFN-alpha-Producing, Bone Marrow Dendritic Cells
- Author(s)
- O'Keeffe, M; Fancke, B; Suter, M; Ramm, G; Clark, J; Wu, L; Hochrein, H;
- Details
- Publication Year 2012-04-15,Volume 188,Issue #8,Page 3774-3783
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Plasmacytoid dendritic cells (pDC) are the producers of type I IFNs in response to TLR9 ligands. However, we have found that when bone marrow is depleted of pDC, the IFN-alpha produced in response to TLR9 ligands is not fully removed. We assign the source of this non-pDC IFN-alpha as a newly described DC type. It displays the high IFN-alpha producing activity of pDC but to a more limited range of viruses. Unlike pDC, the novel DC display high T cell stimulation capacity. Moreover, unlike mouse pDC, they are matured with GM-CSF and are less prone to apoptosis upon activation stimuli, including viruses. We propose that these DC constitute a novel bone marrow inflammatory DC type, ideally geared to linking innate and adaptive immune responses in bone marrow via their potent IFN-alpha production and high T cell stimulatory capacity. The Journal of Immunology, 2012, 188: 3774-3783.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- IN-VIVO; B-CELLS; DIFFERENTIAL PRODUCTION; DENGUE VIRUS; PLASMA-CELLS; MICE; INFECTION; SURVIVAL; DISTINCT; SUBSETS
- Research Division(s)
- Immunology
- Publisher's Version
- https://doi.org/10.4049/jimmunol.1101365
- Terms of Use/Rights Notice
- Copyright © 2012 by The American Association of Immunologists, Inc.
Creation Date: 2012-04-15 12:00:00