Functional genomics approaches in parasitic helminths
- Author(s)
- Hagen, J; Lee, EF; Fairlie, WD; Kalinna, BH;
- Details
- Publication Year 2012-02,Volume 34,Issue #2-3,Page 163-182
- Journal Title
- PARASITE IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- As research on parasitic helminths is moving into the post-genomic era, an enormous effort is directed towards deciphering gene function and to achieve gene annotation. The sequences that are available in public databases undoubtedly hold information that can be utilized for new interventions and control but the exploitation of these resources has until recently remained difficult. Only now, with the emergence of methods to genetically manipulate and transform parasitic worms will it be possible to gain a comprehensive understanding of the molecular mechanisms involved in nutrition, metabolism, developmental switches/maturation and interaction with the host immune system. This review focuses on functional genomics approaches in parasitic helminths that are currently used, to highlight potential applications of these technologies in the areas of cell biology, systems biology and immunobiology of parasitic helminths.
- Publisher
- WILEY-BLACKWELL
- Keywords
- SCHISTOSOMA-MANSONI SPOROCYSTS; MULTILOCULARIS PRIMARY-CELLS; MURINE LEUKEMIA RETROVIRUS; TRANSFECTED BRUGIA-MALAYI; RNA-INTERFERENCE; SELECTABLE MARKER; GENE-EXPRESSION; IN-VITRO; ECHINOCOCCUS-MULTILOCULARIS; TRANSGENE EXPRESSION
- Research Division(s)
- Structural Biology
- Publisher's Version
- https://doi.org/10.1111/j.1365-3024.2011.01306.x
- Terms of Use/Rights Notice
- © 2011 Blackwell Publishing Ltd
Creation Date: 2012-02-01 12:00:00