The NF-kappa B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties

Gugasyan, R; Horat, E; Kinkel, SA; Ross, F; Grigoriadis, G; Gray, D; O&#39;Keeffe, M; Berzins, SP; Belz, GT; Grumont, RJ; Banerjee, A; Strasser, A; Godfrey, DI; Tsichlis, PN; Gerondakis, S

Author(s): Gugasyan, R; Horat, E; Kinkel, SA; Ross, F; Grigoriadis, G; Gray, D; O'Keeffe, M; Berzins, SP; Belz, GT; Grumont, RJ; Banerjee, A; Strasser, A; Godfrey, DI; Tsichlis, PN; Gerondakis, S;
Details: Publication Year 2012-02-01,Volume 31,Issue #3,Page 692-706
Journal Title: EMBO JOURNAL
Publication Type: Journal Article
Abstract: The role of specific members of the NF-kappa B family of transcription factors in CD8 T-cell selection and development is largely unknown. Here, we show that mice lacking NF-kappa B1 develop a unique population of conventional CD8 single-positive (SP) thymocytes with memory T cell-like properties that populate peripheral immune organs. Development of this memory-like population is not due to PLZF(+) thymocytes and instead coincides with changes in CD8 T-cell selection. These include a reduction in the efficiency of negative selection and a dependence on MHC class Ia or Ib expressed by haematopoietic cells. These findings indicate that NF-kappa B1 regulates multiple events in the thymus that collectively inhibit the excess development of CD8(+) thymocytes with memory cell characteristics. The EMBO Journal (2012) 31, 692-706. doi: 10.1038/emboj.2011.435; Published online 29 November 2011
Publisher: NATURE PUBLISHING GROUP
Keywords: NF-KAPPA-B; POSITIVE SELECTION; IN-VIVO; HEMATOPOIETIC-CELLS; NEGATIVE SELECTION; DENDRITIC CELLS; LYMPHOCYTE DEVELOPMENT; SIGNALING PATHWAY; TRANSGENIC MICE; DISTINCT ROLES
Research Division(s): Molecular Medicine; Molecular Genetics Of Cancer; Molecular Immunology
Link To PubMed Central Version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273395/
Publisher's Version: https://doi.org/10.1038/emboj.2011.435

Creation Date: 2012-02-01 12:00:00