The Heat Shock Protein 40 Family of the Malaria Parasite Plasmodium falciparum
- Details
- Publication Year 2011-12,Volume 63,Issue #12,Page 1081-1086
- Journal Title
- IUBMB LIFE
- Publication Type
- Journal Article
- Abstract
- Few diseases have had such a profound influence on human evolution and history as malaria. Despite intense efforts malaria infection continues to be a major killer. The causative agent of malaria, the unicellular eukaryote Plasmodium, displays a fascinating biology in which ubiquitous cellular concepts are modified to serve the particular needs of the malaria parasite. In this review, we explore how Plasmodium utilizes the heat shock protein 40 system, a chaperone system that ensures correct protein folding under normal and stress conditions. We highlight the peculiarities of the Plasmodium system and discuss whether any components of the system might be exploited for intervention strategies against this debilitating disease. (C) 2011 IUBMB IUBMB Life, 63(12): 1081-1086, 2011
- Publisher
- WILEY-BLACKWELL
- Keywords
- ERYTHROCYTE SURFACE-ANTIGEN; INFECTED ERYTHROCYTE; HOST ERYTHROCYTE; HSP40 PROTEINS; RESA PROTEIN; CHAPERONE; VIRULENCE; DNAJ; TRANSLOCATION; STABILITY
- Publisher's Version
- https://doi.org/10.1002/iub.525
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2011-12-01 12:00:00