Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin
Details
Publication Year 2011-12-02, Volume 9, Issue #6, Page 527-540
Journal Title
CELL STEM CELL
Publication Type
Journal Article
Abstract
Colony-forming units fibroblast (CFU-Fs), analogous to those giving rise to bone marrow (BM) mesenchymal stem cells (MSCs), are present in many organs, although the relationship between BM and organ-specific CFU-Fs in homeostasis and tissue repair is unknown. Here we describe a population of adult cardiac-resident CFU-Fs (cCFU-Fs) that occupy a perk vascular, adventitial niche and show broad trans-germ layer potency in vitro and in vivo. CRE lineage tracing and embryo analysis demonstrated a proepicardial origin for cCFU-Fs. Furthermore, in BM transplantation chimeras, we found no interchange between BM and cCFU-Fs after aging, myocardial infarction, or BM stem cell mobilization. BM and cardiac and aortic CFU-Fs had distinct CRE lineage signatures, indicating that they arise from different progenitor beds during development. These diverse origins for CFU-Fs suggest an underlying basis for differentiation biases seen in different CFU-F populations, and could also influence their capacity for participating in tissue repair.
Publisher
CELL PRESS
Keywords
CORONARY-ARTERY FORMATION; NEURAL CREST CELLS; BONE-MARROW; PROGENITOR CELLS; C-KIT; PERIPHERAL-BLOOD; MAMMALIAN HEART; IN-VITRO; CFU-F; INJURY
Rights Notice
Copyright © 2011 Elsevier Inc. All rights reserved.


Creation Date: 2011-12-02 12:00:00
Last Modified: 0001-01-01 12:00:00
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