Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses
- Author(s)
- Chang, PP; Barral, P; Fitch, J; Pratama, A; Ma, CS; Kallies, A; Hogan, JJ; Cerundolo, V; Tangye, SG; Bittman, R; Nutt, SL; Brink, R; Godfrey, DI; Batista, FD; Vinuesa, CG;
- Details
- Publication Year 2012-01,Volume 13,Issue #1,Page 35-43
- Journal Title
- NATURE IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Lipid antigens trigger help from natural killer T cells (NKT cells) for B cells, and direct conjugation of lipid agonists to antigen profoundly augments antibody responses. Here we show that in vivo, NKT cells engaged in stable and prolonged cognate interactions with B cells and induced the formation of early germinal centers. Mouse and human NKT cells formed CXCR5(+)PD-1(hi) follicular helper NKT cells (NKT(FH) cells), and this process required expression of the transcriptional repressor Bcl-6, signaling via the coreceptor CD28 and interaction with B cells. NKT(FH) cells provided direct cognate help to antigen-specific B cells that was dependent on interleukin 21 (IL-21). Unlike T cell-dependent germinal centers, those driven by NKT(FH) cells did not generate long-lived plasma cells. Our results demonstrate the existence of a Bcl-6-dependent subset of NKT cells specialized in providing help to B cells.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- KILLER T-CELLS; GERMINAL-CENTERS; CYTOKINE PRODUCTION; ANTIBODY-RESPONSES; IN-VIVO; ANTIGEN; DIFFERENTIATION; EXPANSION; COSTIMULATION; ACTIVATION
- Research Division(s)
- Molecular Immunology
- Publisher's Version
- https://doi.org/10.1038/ni.2166
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Creation Date: 2012-01-01 12:00:00