Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
Details
Publication Year 2012-01-15, Volume 26, Issue #2, Page 120-125
Journal Title
GENES & DEVELOPMENT
Publication Type
Journal Article
Abstract
Acute myeloid leukemia (AML) frequently relapses after initial treatment. Drug resistance in AML has been attributed to high levels of the anti-apoptotic Bcl-2 family members Bcl-x(L) and Mcl-1. Here we report that removal of Mcl-1, but not loss or pharmacological blockade of Bcl-x(L), Bcl-2, or Bcl-w, caused the death of transformed AML and could cure disease in AML-afflicted mice. Enforced expression of selective inhibitors of prosurvival Bcl-2 family members revealed that Mcl-1 is critical for survival of human AML cells. Thus, targeting of Mcl-1 or regulators of its expression may be a useful strategy for the treatment of AML.
Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Keywords
MARROW-CELLS; STEM-CELLS; PROTEINS; GENE; CHEMOTHERAPY; EXPRESSION; SURVIVAL; BINDING; FAMILY; MICE
WEHI Research Division(s)
Cancer And Haematology; Molecular Genetics Of Cancer; Structural Biology
Rights Notice
Copyright © 2012 by Cold Spring Harbor Laboratory Press


Creation Date: 2012-01-15 12:00:00
Last Modified: 0001-01-01 12:00:00
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