PfSET10, a Plasmodium falciparum Methyltransferase, Maintains the Active var Gene in a Poised State during Parasite Division
Details
Publication Year 2012-01-19, Volume 11, Issue #1, Page 7-18
Journal Title
CELL HOST & MICROBE
Publication Type
Journal Article
Abstract
A major virulence factor of the malaria parasite Plasmodium falciparum is erythrocyte membrane protein 1 (PfEMP1), a variant protein expressed on the infected erythrocyte surface. PfEMP1 is responsible for adherence of infected erythrocytes to the endothelium and plays an important role in pathogenesis. Mutually exclusive transcription and switched expression of one of 60 var genes encoding PfEMP1 in each parasite genome provides a mechanism for antigenic variation. We report the identification of a parasite protein, designated PfSET10, which localizes exclusively to the perinuclear active var gene expression site. PfSET10 is a histone 3 lysine 4 methyltransferase required to maintain the active var gene in a poised state during division for reactivation in daughter parasites, and as such is required for P. falciparum antigenic variation. PfSET10 likely maintains the transcriptionally permissive chromatin environment of the active var promoter and thus retains memory for heritable transmission of epigenetic information during parasite division.
Publisher
CELL PRESS
Keywords
MUTUALLY EXCLUSIVE EXPRESSION; HISTONE H3; INFECTED ERYTHROCYTES; MALARIA PARASITE; ANTIGENIC VARIATION; VIRULENCE GENES; SACCHAROMYCES-CEREVISIAE; ECTOPIC RECOMBINATION; LYSINE-4 METHYLATION; ADHESION MOLECULE-1
WEHI Research Division(s)
Infection And Immunity
Rights Notice
Copyright © 2012 Elsevier Inc. All rights reserved


Creation Date: 2012-01-19 12:00:00
Last Modified: 0001-01-01 12:00:00
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