Activation-Induced B Cell Fates Are Selected by Intracellular Stochastic Competition
Details
Publication Year 2012-01-20, Volume 335, Issue #6066, Page 338-341
Journal Title
SCIENCE
Publication Type
Journal Article
Abstract
In response to stimulation, B lymphocytes pursue a large number of distinct fates important for immune regulation. Whether each cell's fate is determined by external direction, internal stochastic processes, or directed asymmetric division is unknown. Measurement of times to isotype switch, to develop into a plasmablast, and to divide or to die for thousands of cells indicated that each fate is pursued autonomously and stochastically. As a consequence of competition between these processes, censorship of alternative outcomes predicts intricate correlations that are observed in the data. Stochastic competition can explain how the allocation of a proportion of B cells to each cell fate is achieved. The B cell may exemplify how other complex cell differentiation systems are controlled.
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Keywords
IMMUNE-RESPONSES; PLASMA-CELL; T-CELLS; LYMPHOCYTE DIVISION; POPULATION-DYNAMICS; DIFFERENTIATION; MECHANISM; MODEL; PROLIFERATION; VARIABILITY
WEHI Research Division(s)
Immunology
Rights Notice
© 2013 American Association for the Advancement of Science. All Rights Reserved.


Creation Date: 2012-01-20 12:00:00
Last Modified: 0001-01-01 12:00:00
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