Boosting antibody responses by targeting antigens to dendritic cells
Details
Publication Year 2012-02, Volume 33, Issue #2, Page 71-77
Journal Title
TRENDS IN IMMUNOLOGY
Publication Type
Journal Article
Abstract
Delivering antigens directly to dendritic cells (DCs) in situ, by injecting antigens coupled to antibodies specific for DC surface molecules, is a promising strategy for enhancing vaccine efficacy. Enhanced cytotoxic T cell responses are obtained if an adjuvant is co-administered to activate the DC. Such DC targeting is also effective at enhancing humoral immunity, via the generation of T follicular helper cells. Depending on the DC surface molecule targeted, antibody production can be enhanced even in the absence of adjuvants. In the case of Clec9A as the DC surface target, enhanced antibody production is a consequence of the DC-restricted expression of the target molecule. Few other cells absorb the antigen antibody construct, therefore, it persists in the bloodstream, allowing sustained antigen presentation, even by non-activated DCs.
Publisher
ELSEVIER SCI LTD
Keywords
C-TYPE LECTIN; CD8(+) T-CELLS; SUBSETS IN-VIVO; CROSS-PRESENTATION; DC-SIGN; ANTITUMOR IMMUNITY; B-LYMPHOCYTES; RECEPTOR; INDUCTION; ACTIVATION
WEHI Research Division(s)
Immunology
Rights Notice
Copyright © 2013 Elsevier B.V. All rights reserved. ScienceDirect® is a registered trademark of Elsevier B.V.


Creation Date: 2012-02-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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