Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum
- Author(s)
- Tham, WH; Healer, J; Cowman, AF;
- Details
- Publication Year 2012-01,Volume 28,Issue #1,Page 23-30
- Journal Title
- TRENDS IN PARASITOLOGY
- Publication Type
- Journal Article
- Abstract
- The global agenda for malaria eradication would benefit from development of a highly efficacious vaccine that protects against disease and interrupts transmission of Plasmodium falciparum. It is likely that such a vaccine will be multi-component, with antigens from different stages of the parasite life cycle. In this review, inclusion of blood stage antigens in such a vaccine is discussed. Erythrocyte binding-like (EBL) and P. falciparum reticulocyte binding-like (PfRh) proteins are reviewed with respect to their function in erythrocyte invasion, their role in eliciting antibodies contributing to protective immunity and reduction of invasion, leading subsequently to inhibition of parasite multiplication.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- YOELII ADHESIVE PROTEINS; ANTIBODY-RESPONSES; INVASION PATHWAYS; MALARIA VACCINE; RECEPTOR SPECIFICITY; MEROZOITE ANTIGENS; GLYCOPHORIN-A; LIGAND; VIVAX; HOMOLOG
- Research Division(s)
- Infection And Immunity
- Publisher's Version
- https://doi.org/10.1016/j.pt.2011.10.002
- Terms of Use/Rights Notice
- Copyright © 2011 Published by Elsevier Ltd.
Creation Date: 2012-01-01 12:00:00