Proteomic analysis of colorectal cancer: discovering novel biomarkers
Details
Publication Year 2005-10, Volume 2, Issue #5, Page 681-692
Journal Title
EXPERT REVIEW OF PROTEOMICS
Publication Type
Journal Article
Abstract
Colorectal cancer is one of the most common cancers in the Western world. When detected at an early stage, the majority of cancers can be cured with current treatment modalities. However, most cancers present at an intermediate stage. The discovery of sensitive and specific biomarkers has the potential to improve preclinical diagnosis of primary and recurrent colorectal cancer, and holds the promise of prognostic and therapeutic application. Current biomarkers such as carcinoembryonic antigen lack sensitivity and specificity for general population screening. This review alms to highlight the role of current proteomic technologies in the discovery and validation of potential blomarkers with a view to translation to the clinic.
Publisher
FUTURE DRUGS LTD
Keywords
TANDEM MASS-SPECTROMETRY; HUMAN COLON-CANCER; FECAL-OCCULT-BLOOD; HUMAN PLASMA PROTEOME; 2-DIMENSIONAL GEL-ELECTROPHORESIS; MULTIPLE INTESTINAL NEOPLASIA; LASER CAPTURE MICRODISSECTION; FREE-FLOW ELECTROPHORESIS; HUMAN PROSTATE-CANCER; CODED AFFINITY TAG
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2005-10-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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