The wound repair response controls outcome to cutaneous leishmaniasis
- Author(s)
- Sakthianandeswaren, A; Elso, CM; Simpson, K; Curtis, JM; Kumar, B; Speed, TP; Handman, E; Foote, SJ;
- Details
- Publication Year 2005-10-25,Volume 102,Issue #43,Page 15551-15556
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Publication Type
- Journal Article
- Abstract
- Chronic microbial infections are associated with fibrotic and inflammatory reactions known as granulomas showing similarities to wound-healing and tissue repair processes. We have previously mapped three leishmaniasis susceptibility loci, designated Imr1, -2, and -3, which exert their effect independently of T cell immune responses. Here, we show that the wound repair response is critically important for the rapid cure in murine cutaneous leishmaniasis caused by Leishmania major. Mice congenic for leishmaniasis resistance loci, which cured their lesions more rapidly than their susceptible parents, also expressed differentially genes involved in tissue repair, laid down more ordered collagen fibers, and healed punch biopsy wounds more rapidly. Fibroblast monolayers from these mice repaired in vitro wounds faster, and this process was accelerated by supernatants from infected macrophages. Because these effects are independent of T cell-mediated immunity, we conclude that the rate of wound healing is likely to be an important component of innate immunity involved in resistance to cutaneous leishmaniasis.
- Publisher
- NATL ACAD SCIENCES
- Keywords
- MAJOR INFECTION; DISEASE SUSCEPTIBILITY; GRANULOMA-FORMATION; MICE; TUBERCULOSIS; EXPRESSION; MATRIX; SEVERITY; CHROMOSOME-9; IMMUNOLOGY
- Publisher's Version
- https://doi.org/10.1073/pnas.0505630102
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2005-10-25 12:00:00