Quantitative rules for lymphocyte regulation: the cellular calculus and decisions between tolerance and activation
- Author(s)
- Hodgkin, PD;
- Details
- Publication Year 2005-10,Volume 66,Issue #4,Page 259-266
- Journal Title
- TISSUE ANTIGENS
- Publication Type
- Journal Article
- Abstract
- The innovation of fluorescent division-tracking techniques has elevated our understanding of lymphocytes to a new level. These techniques applied in vitro have identified quantitative rules for lymphocyte differentiation, proliferation and survival that had previously been hidden. The many patterns of quantitative response revealed by these analyses provide a sharp contrast to the traditional idea that T cells must make a binary choice between tolerance and activation. Here, evidence for the classic dogma of two-signal theory and T-T help is re-examined in the light of the new quantitative view to show how logical difficulties can be resolved.
- Publisher
- BLACKWELL PUBLISHING
- Keywords
- DIFFERENT LY ANTIGENS; FUNCTIONAL SUBCLASSES; CD40 LIGAND; T-CELLS; B-CELLS; DIVISION; DIFFERENTIATION; GENERATION; SURVIVAL; INVITRO
- Publisher's Version
- https://doi.org/10.1111/j.1399-0039.2005.00475.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2005-10-01 12:00:00