CD8 alpha(+) dendritic cells selectively present MHC class I-restricted noncytolytic viral and intracellular bacterial antigens in vivo
- Author(s)
- Belz, GT; Shortman, K; Bevan, MJ; Heath, WR;
- Details
- Publication Year 2005-07-01,Volume 175,Issue #1,Page 196-200
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- CD8 alpha(+) dendritic cells (DCs) have been shown to be the principal DC subset involved in priming MHC class I-restricted CTL immunity to a variety of cytolytic viruses, including HSV type 1, influenza, and vaccinia virus. Whether priming of CTLs by CD8 alpha(+) DCs is limited to cytolytic viruses, which may provide dead cellular material for this DC subset, or whether these DCs selectively present intracellular Ags, is unknown. To address this question, we examined Ag presentation to a noncytolytic virus, lymphocytic choriomeningitis virus, and to an intracellular bacterium, Listeria monocytogenes. We show that regardless of the type of intracellular infection, CD8 alpha(+) DCs are the principal DC subset that initiate CD8(+) T cell immunity.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- LYMPHOCYTIC CHORIOMENINGITIS VIRUS; CD8 T-CELLS; LISTERIA-MONOCYTOGENES; SURFACE PHENOTYPE; LANGERHANS CELLS; MOUSE THYMUS; INFECTION; RESPONSES; IMMUNITY; EXPRESSION
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2005-07-01 12:00:00