The art and design of genetic screens: Mouse
- Author(s)
- Kile, BT; Hilton, DJ;
- Details
- Publication Year 2005-07,Volume 6,Issue #7,Page 557-567
- Journal Title
- NATURE REVIEWS GENETICS
- Publication Type
- Journal Article
- Abstract
- Humans are mammals, not bacteria or plants, yeast or nematodes, insects or fish. Mice are also mammals, but unlike gorilla and goat, fox and ferret, giraffe and jackal, they are suited perfectly to the laboratory environment and genetic experimentation. In this review, we will summarize the tools, tricks and techniques for executing forward genetic screens in the mouse and argue that this approach is now accessible to most biologists, rather than being the sole domain of large national facilities and specialized genetics laboratories.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- EMBRYONIC STEM-CELLS; ETHYL-N-NITROSOUREA; MULTIPLE INTESTINAL NEOPLASIA; NESTED CHROMOSOMAL DELETIONS; CIRCADIAN CLOCK GENE; ENU MUTAGENESIS; GENOME-WIDE; FUNCTIONAL ANNOTATION; TRANSCRIPTION FACTOR; SIGNAL-TRANSDUCTION
- Publisher's Version
- https://doi.org/10.1038/nrg1636
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2005-07-01 12:00:00