Targeting lymphocyte Peyer's patch adhesion molecule-1: A relay approach to gut immunization
- Author(s)
- McKenzie, BS; Corbett, AJ; Brady, JL; Boyle, JS; Rockman, SP; Lew, AM;
- Details
- Publication Year 2005-05-25,Volume 23,Issue #28,Page 3668-3678
- Journal Title
- VACCINE
- Publication Type
- Journal Article
- Abstract
- Targeting vaccines to dendritic cells (DCs) can enhance responses to weak vaccine antigens. Although there are molecules that are relatively specific for the various DC subsets, there are none that are both region-specific and DC-specific, This has provided some limitation to targeting regional DC populations. We proposed that these limits could be overcome by targeting antigens not to the DC subsets directly but to cells that persistently seek out and closely interact with DCs. namely lymphocytes. To investigate this hypothesis. we targeted antigens to a unique population of gut-homing lymphocytes and then looked at the induction of immune responses at this site. Using an anti-LPAM-1 (Lymphocyte Peyer's patch adhesion molecule-1: α(4)β(7) integrin) monoclonal antibody (mAb) as it model antigen. we found that targeting gut-homing lymphocytes could significantly elevate the gut mucosal IgA response. Moreover. such it strategy greatly elevated the systemic IgG as well as IgA response. We found that LPAM-1-targeting enhanced the localization of antigen to both the systemic and mucosal lymphoid compartments where both IgA and IgG responses were induced. We also found that my parenteral route of delivery sufficed. Overall. targeting unique populations of lymphocytes may, provide a strategy for ferrying antigen to sites that such lymphocytes home to. © 2005 Elsevier Ltd. All rights reserved.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- CD8-ALPHA(+) DENDRITIC CELLS; MUCOSAL VASCULAR ADDRESSIN; IN-VIVO; ANTIBODY-RESPONSES; T-CELLS; B-CELLS; ALPHA-4-BETA-7 INTEGRIN; CROSS-PRESENTATION; IMMUNE-RESPONSES; CUTTING EDGE
- Publisher's Version
- https://doi.org/10.1016/j.vaccine.2005.02.016
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2005-05-25 12:00:00