Early asymmetry of gene transcription in embryonic human left and right cerebral cortex
- Author(s)
- Sun, T; Patoine, C; Abu-Khalil, A; Visvader, J; Sum, E; Cherry, TJ; Orkin, SH; Geschwind, DH; Walsh, CA;
- Details
- Publication Year 2005-06-17,Volume 308,Issue #5729,Page 1794-1798
- Journal Title
- SCIENCE
- Publication Type
- Journal Article
- Abstract
- The human left and right cerebral hemispheres are anatomically and functionally asymmetric. To test whether human cortical asymmetry has a molecular basis, we studied gene expression levels between the left and right embryonic hemispheres using serial analysis of gene expression (SAGE). We identified and verified 27 differentialty expressed genes, which suggests that human cortical asymmetry is accompanied by early, marked transcriptional asymmetries. LMO4 is consistently more highly expressed in the right perisylvian human cerebral cortex than in the left and is essential for cortical development in mice, suggesting that human left-right specialization reflects asymmetric cortical development at early stages.
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Keywords
- HUMAN-BRAIN; HANDEDNESS; SPEECH; LATERALITY; EVOLUTION; MICE
- Publisher's Version
- https://doi.org/10.1126/science.1110324
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2005-06-17 12:00:00