Immunological processes in malaria pathogenesis
- Author(s)
- Schofield, L; Grau, GE;
- Details
- Publication Year 2005-09,Volume 5,Issue #9,Page 722-735
- Journal Title
- NATURE REVIEWS IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Malaria is possibly the most serious infectious disease of humans, infecting 5 - 10% of the world's population, with 300 - 600 million clinical cases and more than 2 million deaths annually. Adaptive immune responses in the host limit the clinical impact of infection and provide partial, but incomplete, protection against pathogen replication; however, these complex immunological reactions can contribute to disease and fatalities. So, appropriate regulation of immune responses to malaria lies at the heart of the host - parasite balance and has consequences for global public health. This Review article addresses the innate and adaptive immune mechanisms elicited during malaria that either cause or prevent disease and fatalities, and it considers the implications for vaccine design.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- EXPERIMENTAL CEREBRAL MALARIA; TUMOR-NECROSIS-FACTOR; PLASMODIUM-FALCIPARUM MALARIA; CD1D-RESTRICTED NKT CELLS; ENHANCED VASCULAR-PERMEABILITY; NATURAL-KILLER COMPLEX; PROTEIN-KINASE-C; T-CELLS; GLYCOSYLPHOSPHATIDYLINOSITOL TOXIN; SIGNAL-TRANSDUCTION
- Publisher's Version
- https://doi.org/10.1038/nri1686
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2005-09-01 12:00:00