Heterogeneity of thymic dendritic cells
- Author(s)
- Wu, L; Shortman, K;
- Details
- Publication Year 2005-08,Volume 17,Issue #4,Page 304-312
- Journal Title
- SEMINARS IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Thymus is the site of generation and selection of T-lymphocytes. It also contains phenotypically and functionally distinct dendritic cell (DC) populations, including conventional DC (cDC) and plasmacytoid DC (pDC). Thymic cDC are heterogeneous and contain two subsets: a major subset derived from the precursors within thymus, and a minor subset presumably of extrathymic origin. Increasing evidence suggest that thymic cDC can cross-present self-antigens to developing thymocytes and play an important role in thymocyte negative selection and central tolerance induction. Thymic pDC can produce type-1 interferon upon appropriate activation. However, their role in a steady state thymus is currently unclear. (c) 2005 Elsevier Ltd. All rights reserved.
- Publisher
- ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
- Keywords
- COMMON MYELOID PROGENITOR; COLONY-STIMULATING FACTOR; MOUSE PLASMACYTOID CELLS; CLONAL DELETION; PRECURSOR CELLS; T-CELLS; IN-VIVO; POSITIVE SELECTION; NATURAL-KILLER; CD8 EXPRESSION
- Publisher's Version
- https://doi.org/10.1016/j.smim.2005.05.001
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2005-08-01 12:00:00