Invasion of red blood cells by malaria parasites
- Author(s)
- Cowman, AF; Crabb, BS;
- Details
- Publication Year 2006-02-24,Volume 124,Issue #4,Page 755-766
- Journal Title
- CELL
- Publication Type
- Journal Article
- Abstract
- The malaria parasite is the most important member of the Apicomplexa, a large and highly successful phylum of intracellular parasites. Invasion of host cells allows apicomplexan parasites access to a rich source of nutrients in a niche that is largely protected from host defenses. All Apicomplexa adopt a common mode of host-cell entry, but individual species incorporate unique features and utilize a specific set of ligand-receptor interactions. These adhesins ultimately connect to a parasite actin-based motor, which provides the power for invasion. While some Apicomplexa can invade many different host cells, the disease-associated blood-stage form of the malaria parasite is restricted to erythrocytes.
- Publisher
- CELL PRESS
- Keywords
- APICAL MEMBRANE ANTIGEN-1; MEROZOITE SURFACE PROTEIN-1; PLASMODIUM-FALCIPARUM MEROZOITES; TOXOPLASMA-GONDII; VACCINE CANDIDATE; ERYTHROCYTE INVASION; APICOMPLEXAN PARASITES; CRYSTAL-STRUCTURE; GLIDING MOTILITY; PARASITOPHOROUS VACUOLE
- Publisher's Version
- https://doi.org/10.1016/j.cell.2006.02.006
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2006-02-24 12:00:00