T lineage progenitors: the earliest steps en route to T lymphocytes
- Author(s)
- Wu, L;
- Details
- Publication Year 2006-04,Volume 18,Issue #2,Page 121-126
- Journal Title
- CURRENT OPINION IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- T lymphocyte development in the thymus is a tightly regulated stepwise process. The identification and characterization of the earliest T lineage progenitors and their downstream progeny now enables the study of important cellular and molecular mechanisms that control and regulate T lineage commitment and differentiation. Significant progress has been made recently on the developmental relationships of the various cells with T cell progenitor activity identified in mouse bone marrow, blood and thymus, and on the molecular regulation of progenitor homing to the thymus. The essential role of Notch-1 signalling in intrathymic T lineage commitment and subsequent T cell development has been clearly documented.
- Publisher
- CURRENT BIOLOGY LTD
- Keywords
- COMMON LYMPHOID PROGENITORS; MURINE FETAL BLOOD; ADULT-MOUSE THYMUS; BONE-MARROW; CELL PROGENITORS; DENDRITIC CELLS; PRECURSOR CELLS; IN-VITRO; NOTCH; DIFFERENTIATION
- Publisher's Version
- https://doi.org/10.1016/j.coi.2006.01.006
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2006-04-01 12:00:00