Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
- Author(s)
- Holmes, ML; Carotta, S; Corcoran, LM; Nutt, SL;
- Details
- Publication Year 2006-04-15,Volume 20,Issue #8,Page 933-938
- Journal Title
- GENES & DEVELOPMENT
- Publication Type
- Journal Article
- Abstract
- Early B-lymphopoiesis requires the growth-factor receptors, IL-7R and Flt3, and the activity of a number of transcription factors. One factor, Pax5, is required for commitment to the B-cell lineage, although the molecular mechanism by which this occurs is unknown. We demonstrate here that an important function of Pax5 is to repress Flt3 transcription in B-cell progenitors, as Pax5-deficient pro-B cells express abundant Flt3 that is rapidly silenced upon the reintroduction of Pax5, whereas enforced expression of Flt3 in wild-type progenitors significantly impairs B-cell development. These findings demonstrate that the repression of Flt3 by Pax5 is essential for normal B-lymphopoiesis.
- Publisher
- COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
- Keywords
- BONE-MARROW; STEM-CELLS; HEMATOPOIETIC PROGENITOR; DENDRITIC CELLS; C-KIT; DIFFERENTIATION; MICE; IDENTIFICATION; INTERLEUKIN-7; LIGAND
- Publisher's Version
- https://doi.org/10.1101/gad.1396206
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2006-04-15 12:00:00